https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27772 Wed 11 Apr 2018 15:54:06 AEST ]]> Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16760 −/− PyMT mice compared to Cd151+/+ PyMT littermate controls, this result was only approaching significance (Log-rank test P-value =0.0536). Interestingly, Cd151 deletion resulted in significantly reduced numbers and size of primary tumors but did not appear to affect the number or size of metastases in the MMTV/PyMT mice. Intriguingly, no differences in the expression of markers of cell proliferation, apoptosis and blood vessel density was observed in the primary tumors. Conclusion: The findings from this study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes and strongly support its relevance as a potential therapeutic target to delay breast cancer progression.]]> Wed 11 Apr 2018 10:43:04 AEST ]]> Characterization of the early molecular changes in the glomeruli of Cd151-/- mice highlights induction of mindin and MMP-10 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33471 -/- mice compared to Cd151+/+ controls. This study identified 72 up-regulated and 183 down-regulated genes in FVB/N Cd151-/- compared to Cd151+/+ glomeruli (p<0.05). Further analysis highlighted induction of the matrix metalloprotease MMP-10 and the extracellular matrix protein mindin (encoded by Spon2) in the diseased FVB/N Cd151-/- GBM that did not occur in the C57BL/6 diseased-resistant strain. Interestingly, mindin was also detected in urinary samples of FVB/N Cd151-/- mice, underlining its potential value as a biomarker for glomerular diseases associated with GBM alterations. Gene set enrichment and pathway analysis of the microarray dataset showed enrichment in axon guidance and actin cytoskeleton signalling pathways as well as activation of inflammatory pathways. Given the known function of mindin, its early expression in the diseased GBM could represent a trigger of both further podocyte cytoskeletal changes and inflammation, thereby playing a key role in the mechanisms of disease progression.]]> Tue 03 Sep 2019 18:26:44 AEST ]]> The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10448 Sat 24 Mar 2018 08:08:01 AEDT ]]> Nerve-cancer cell cross-talk: a novel promoter of tumor progression https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28919 Sat 24 Mar 2018 07:25:58 AEDT ]]> Tetraspanin CD9 is regulated by MiR-518f-5p and functions in breast cell migration and in vivo tumor growth https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44184 Mon 10 Oct 2022 10:48:32 AEDT ]]>